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VU 0465350
CAS No. 1414843-61-0
VU 0465350( VU0465350 | VU5350 | VU 5350 )
Catalog No. M11718 CAS No. 1414843-61-0
A potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 92.3 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameVU 0465350
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 92.3 nM.
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DescriptionA potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 92.3 nM; shows no activity for ALK2/4/5, also shows affinity for TGFBR2, VEGFR2 and AMPK; blocks SMAD phosphorylation in vitro and in vivo, and enhances liver regeneration after partial hepatectomy.
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In Vitro——
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In Vivo——
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SynonymsVU0465350 | VU5350 | VU 5350
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PathwayTGF-beta/Smad
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TargetTGFBR
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RecptorTGFBR
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Research Area——
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Indication——
Chemical Information
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CAS Number1414843-61-0
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Formula Weight318.38
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Molecular FormulaC19H18N4O
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C)OC1=CC=C(C=C1)C2=CC3=NC=C(N3C=C2)C4=CNN=C4
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Chemical Name7-(4-isopropoxyphenyl)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyridine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tsugawa D, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):549-58.
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